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师资介绍
郝大程
 
姓  名      郝大程 
职  称      副教授     
所学专业      生物技术                         
研究方向      药用植物,药物代谢,应用微生物学  
联系电话      0411-84107585
Email            hao@djtu.edu.cn                 
 
 
 
学习工作经历
  1989 月至1994 7  西安交通大学医学院 医学学士
  2000 月至2002 12 新加坡国立大学医学院 科学硕士
  2004 月至2008 1  大连化学物理研究所 工学博士
  2008 3  月至                   大连交通大学环境化工学院/生物技术研究所讲师  
 
发表论文著作情况
1. Hao DC, Yang L, Xiao PG. The first insight into the Taxus genome via fosmid library construction and end sequencing. Mol Genet Genomics 2011 285: 197-205
2. Hao DC, Xiao PG. Prediction of sites under adaptive evolution in flavin containing monooxygenases:  selection pattern revisited. Chinese Science Bulletin 2011 DOI: 10.1007/s11434-010-0000-2 In press
3. Hao DC, Feng Y, Xiao RR, Xiao PG. Non-neutral nonsynonymous single nucleotide polymorphisms in human ABC transporters: the first comparison of six prediction methods. Pharmacol Rep 2011 In press
4. Hao DC, Xiao PG, Chen SL. Phenotype prediction of nonsynonymous single nucleotide polymorphisms in human phase II drug/xenobiotic metabolizing enzymes: perspectives on molecular evolution. Sci China Life Sci. 2010 53(10):1252-62
5. Hao DC, Chen SL, Xiao PG. Sequence characteristics and divergent evolution of the chloroplast psbA-trnH noncoding region in gymnosperms. J Appl Genet. 2010;51(3):259-73
6. Hao DC, Mu J, Chen SL, Xiao PG. Physicochemical evolution and positive selection of the gymnosperm matK proteins. J Genet 2010 89(1):81-9
7. Hao DC, Mu J, Xiao PG. Molecular evolution and positive Darwinian selection of the gymnosperm
    photosynthetic Rubisco enzyme. Bot Stud 2010 51(4): 491-510
8. Hao DC, Chen SL, Xiao PG. Molecular evolution and positive Darwinian selection of the chloroplast maturase matK. J Plant Res. 2010 123(2):241-7.
9. Hao DC, Chen S, Xiao P. Molecular phylogeny, long-term evolution and functional divergence of flavin-containing monooxygenases. Genetica 2009 137(2):173-187
10. Hao da C, Huang B, Yang L. Molecular evolution of paclitaxel biosynthetic genes TS and DBAT of Taxus species. Genetica 2009 135(2): 123-135
11. Hao DC, Huang B, Chen SL, Mu J. Molecular evolution and phylogenetic analysis of the chloroplast trnL-trnF region in Taxaceae and Cephalotaxaceae. Biochemical Genetics 2009 47(5-6): 351-369
12. Hao DC, Ge GB, Yang L. Bacterial diversity of Taxus rhizosphere: culture-independent and culture-dependent approaches. FEMS Microbiology Letters 2008 284(2):204-212
 
综述
1. Hao DC, Chen SL, Xiao PG, Peng Y. Authentication of Medicinal Plants by DNA Based Markers and Genomics. Chinese Herbal Med 2010, 2(4): 250-261
2. 郝大程, 陈士林,肖培根.基于分子生物学和基因组学的药用植物鉴定.《药物生物技术》2009年,16卷5期490-494
3. 郝大程, 陈士林,肖培根.基于分子生物学和基因组学的植物根际微生物研究.《微生物学通报》2009年36卷6期892-899
4. 郝大程,肖培根.人药物代谢酶细胞色素P450在大肠杆菌中的功能表达.《中国生物工程杂志》2009年,29卷7期94-101